Hydrogenosome metabolism is the key target for 1 antiparasitic activity of resveratrol against 2 Trichomonas
نویسندگان
چکیده
Corresponding author 13 Laboratorio de Parasitología, 14 Instituto de Investigación y Análisis Alimentarios, 15 c/ Constantino Candeira s/n, 16 15782, Santiago de Compostela (La Coruña), Spain 17 Tel: +34 981 56 31 00 18 Fax: + 34 881 81 60 27 19 E-mail address: [email protected] 20 21 Copyright © 2013, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00009-13 AAC Accepts, published online ahead of print on 11 March 2013
منابع مشابه
Hydrogenosome metabolism is the key target for antiparasitic activity of resveratrol against Trichomonas vaginalis.
Metronidazole (MDZ) and related 5-nitroimidazoles are the recommended drugs for treatment of trichomoniasis, a sexually transmitted disease caused by the protozoan parasite Trichomonas vaginalis. However, novel treatment options are needed, as recent reports have claimed resistance to these drugs in T. vaginalis isolates. In this study, we analyzed for the first time the in vitro effects of the...
متن کاملHydrogenosome metabolism is the key target for 1 antiparasitic activity of resveratrol against 2 Trichomonas vaginalis
Corresponding author 13 Laboratorio de Parasitología, 14 Instituto de Investigación y Análisis Alimentarios, 15 c/ Constantino Candeira s/n, 16 15782, Santiago de Compostela (La Coruña), Spain 17 Tel: +34 981 56 31 00 18 Fax: + 34 881 81 60 27 19 E-mail address: [email protected] 20 21 Copyright © 2013, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. ...
متن کاملHydrogenosome metabolism is the key target for 1 antiparasitic activity of resveratrol against 2 Trichomonas vaginalis 3
Corresponding author 13 Laboratorio de Parasitología, 14 Instituto de Investigación y Análisis Alimentarios, 15 c/ Constantino Candeira s/n, 16 15782, Santiago de Compostela (La Coruña), Spain 17 Tel: +34 981 56 31 00 18 Fax: + 34 881 81 60 27 19 E-mail address: [email protected] 20 21 Copyright © 2013, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. ...
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Pyridoxal-5'-phosphate-dependent cysteine desulfurase (IscS) is an essential enzyme in the assembly of FeS clusters in bacteria as well as in the mitochondria of eukaryotes. Although FeS proteins are particularly important for the energy metabolism of amitochondrial anaerobic eukaryotes, there is no information about FeS cluster formation in these organisms. We identified and sequenced two IscS...
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Diarrhoeal diseases caused by the intestinal parasites Giardia lamblia and Entamoeba histolytica constitute a major global health burden. Nitroimidazoles are first-line drugs for the treatment of giardiasis and amebiasis, with metronidazole 1 being the most commonly used drug worldwide. However, treatment failures in giardiasis occur in up to 20% of cases and development of resistance to metron...
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